|Amount Per Serving||% Daily Value|
|Berberine HCl (from Berberis aristata extract, root)||500 mg||*|
|Alpha Lipoic Acid||50 mg||*|
|Grape Seed Extract||50 mg||*|
DESCRIPTIONBerberine Balance supplies high potency berberine combined with alpha lipoic acid and grape seed extract for blood sugar and cardiovascular support. Grape seed extract is a well known antioxidant with heart health benefits, and alpha lipoic acid helps to support p roper insulin function. †
FUNCTIONSBerberine is a naturally occurring alkaloid and a primary constituent of several plants including barberry, goldenseal, and phellodendron. Recent studies indicate that berberine is a helpful supplement for maintaining cardiometabolic health and is considered effective and safe. † Berberine has been shown to regulate glucose and lipid metabolism in vitro and in vivo. In several clinical trials, berberine supplementation for three months resulted in healthy blood glucose and cholesterol levels. In vivo and in vitro experiments have also shown blood pressure support and vasorelaxatory effects of berberine. Nevertheless, the vascular sites for this activity of berberine are not clear. It seems that berberine acts on both t he endothelium and the underlying vascular smooth muscle to induce vasorelaxation via multiple cellular mechanisms. Berberine’s history of usage in Ayurvedic and Chinese medicine dating back approximately 3,000 years has shown to help maintain a healthy mi crobial balance. † Polyphenols, part of a broad class of bioflavonoids, are commonly found in grape seeds. One type of polyphenols known as proanthocyanidins is highly regarded for their strong antioxidant properties, and for their functions in supportin g the capillaries. Proanthocyanidins appear to be especially effective in neutralizing highly reactive hydroxyl and singlet oxygen radicals. Both of these reactive oxygen species are involved in inflammatory processes. Alpha lipoic acid is a nutritional coenzyme that is involved in the energy metabolism of proteins, carbohydrates and fats, has physiological functions in blood glucose clearance, and is able to scavenge a number of free radicals. This important coenzyme appears to be necessary for the nor mal transport of blood glucose into the cell. This may be explained by its functions in the glucose - metabolizing enzymes, PDH and alpha - KGDH, but some researchers suspect a more direct role in cellular glucose uptake at the cell membrane.
FORMULA (#201131) Each vegetarian capsule contains: Berberine HCl ................................ ................................ ......... 500 mg (from Berberis aristata extract, root) Alpha lipoic acid ................................ ................................ ...... 50 mg Grape Seed extract ................................ ................................ . 50 mg
Other ingredients:Cellulose, dicalcium phosphate, vegetable stearate and silica.
INDICATIONSBerberine Balance is a useful dietary supplement for those individuals who wish to support blood glucose metabolism and/or cholesterol maintenance.
SUGGESTED USEAdults take 1 capsule twice daily or as directed by your health care professional.
SIDE EFFECTSMa y cause gastrointestinal adverse effects in some individuals. Berberine may increase bilirubin levels. Berberine displaces bilirubin from albumin and increases total and unbound bilirubin concentrations. Berberine Balance DRUG INTERACTIONS: Berberine appears to undergo ph ase I hepatic metabolism. There is preliminary evidence that berberine might inhibit cytochrome P450 3A4, 2C9, 2D6 enzymes. Therefore, watch for an increase in the levels of drugs metabolized by these enzymes in patients taking berberine. WARNING: DO NOT TAKE IF PREGNANT OR LACTATING
STORAGEStore in a cool, dry place, away from direct light. Keep out of reach of children.
REFERENCESYifei Zhang, et al. Treatment of Type 2 Diabetes and dyslipidemia with the natural plant alkaloid berberine. J. Clin. E ndocrinol. Metab. published online Apr 8, 2008; , doi: 10.1210/jc.2007 - 2404 Jun Yina, Huili Xing, and Jianping Yeb. Efficacy of Berberine in Patients with Type 2 Diabetes. Metabolism. 2008 May ; 57(5): 712 – 717. GUO Yi. Biochemical pathways in the antiath erosclerotic effect of berberine. Chinese Medical Journal 2008; 121(13):1197 - 1203 Kong W, et al. Berberine is a novel cholesterol - lowering drug working through a unique mechanism distinct from statins. Nat Med. 2004 Dec;10(12):1344 - 51.. Zeng XH, Zeng XJ, Li YY. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2003;92:173 - 6 Amin AH, Subbaiah TV, Abbasi KM. Berberine sulfate: antimicrobial activity, bioassay, and mode of action. Can J Microbiol 1969;15:1067 - 76. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201 - 8. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with Type 2 diabetes by alpha - li poic acid. Arzneimittelforschung 1995;45:872 - 874. Kamenova P. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha - lipoic acid. Hormones (Athens). 2006 Oct - Dec;5(4):251 - 8. Robert L et al: Action of procyanidolic oligomers on vascular permeability. Path Biol 1990;38:608 - 616. Bagchi D, Bagchi M, Stohs SJ, et al. Cellular protection with proanthocyanidins derived from grape seeds. Ann N Y Acad Sci 2002;957:260 - 70 For more information on Berberine Balance , visit douglaslabs .com † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. © 2012 Douglas Laboratories. All Rights Reserved Manufactured for Douglas Laboratories 600 Boyce Road Pittsburgh, PA 15205 800 - 245 - 4440 douglaslabs.com You trust Douglas Laboratories. Your patients trust you.
|Manufacturer Part Number||No|
|Original Product Name||Douglas Laboratories,Berberine balans 60NL|
|Core Product Name||No|
|Product Type||Food supplement|
|Type of units||No|
|Does not contain||No|
|Country of Manufacture||United States|
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