Life Extension, Optimized Folate (L-Methylfolate), 1000 mcg, 100 Veggie Caps

• For Longer Life
• Metabolically Active Form of Folic Acid
• Dietary Supplement

Optimized Folate (L-Methylfolate)

Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function.

Those who take ordinary folate supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called  5-methyltetrahydrofolate (5-MTHF).Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine).

A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise red blood cell folate concentration, an indicator of folate status compared with folic acid supplementation. This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency since it requires no conversion to become metabolically active.

A study of 10 patients with endothelial dysfunction showed complete reversal of endothelial impairment after 5-MTHF supplementation compared with healthy control patients.

People with elevated homocysteine levels have a greater risk of cognitive decline. Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties to enhance the synthesis of acetylcholine in the brain — the neurotransmitter associated with memory.

Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12), vitamin B6, and riboflavin.

Read the entire label and follow directions carefully prior to use.

Take one (1) capsule daily with food, or as recommended by a healthcare practitioner.

• Keep out of reach of children.
• Do not exceed recommended dose.
• Do not purchase if outer seal is broken or damaged.
• When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Store tightly closed in a cool, dry place.