S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.
The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.
SAMe and Neural Health
SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.
SAMe and Liver Function
SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.
Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.
Double-Strength SAMe is sealed in blister packs for freshness and stability.
Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.
Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.
The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring.
Contains nothing other than listed ingredients
Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.
Store product in a cool, dry place to ensure maximum quality.
|Serving Size: 1 tablet|
|Servings Per Container: 30 servings|
|Amount per serving||% Daily Value|
|S-Adenosyl Methionine (from 800 mg of SAMe tosylate disulfate)||400 mg||†|
|† Daily Value not established.|
|Manufacturer Part Number||DRB-00151|
|Original Product Name||Doctor's Best, SAMe 400, Double-Strength, 30 Enteric Coated Tablets|
|Core Product Name||SAMe 400 Double-Strength|
|Product Type||Food supplement|
|Type of units||Tablets|
|Product Criteria||100% Vegetarian, Gluten Free|
|Does not contain||No|
|Country of Manufacture||United States|
Doctor's Best, SAMe 400 Double-Strength, 30 Enteric Coated Tablets was added to your cart
Doctor's Best, SAMe 400 Double-Strength, 30 Enteric Coated Tablets has been removed from your cart