CaAKG Supplement Benefits: Evidence, Dosage & Risks (2026)

Updated: Sep 10, 2026Topvitamine
Calcium alpha-ketoglutarate (CaAKG) is a stable supplemental form of AKG, a Krebs-cycle molecule that naturally declines with age. Early human research links roughly 1 g daily to reduced epigenetic age markers, 6 g daily to modest bone-density improvements in postmenopausal women, and 3-4 g daily to exercise performance support. Evidence is promising but preliminary, and while CaAKG appears well tolerated, long-term safety data — especially for people with kidney disease or kidney stone history — is limited. This guide grades every claimed benefit by evidence quality, then covers dosage, timing, side effects, and how to choose a quality supplement.
CaAKG supplement benefits
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