Cognitive enhancers is a broad term that covers substances, strategies, and approaches researchers study for their effects on attention, memory, and mental flexibility. The science behind cognitive enhancers sits at the intersection of neuroscience, psychology, and pharmacology, examining how different agents influence brain networks and neurotransmitter systems. Research often looks at how context, baseline performance, and task demands shape outcomes, which means effects can vary widely across studies and individuals. By framing cognitive enhancers in this way, we can explore what the science says about potential benefits while acknowledging its complexities. When scientists discuss the potential benefits of cognitive enhancers, they typically examine whether these approaches can yield sharper focus, improved working memory, or clearer mental processing on specific tasks. The evidence is nuanced: gains are often small and task-dependent, and they can depend on an individual’s starting point and the rigor of the study design. Placebo effects and expectancy also play a role in some findings, so researchers emphasize interpreting results in context and considering variability among participants. This reality underlines why any claims about universal outcomes should be approached with caution. Our top picks for sharper focus, memory, and mental clarity emphasize non-pharmacological cognitive enhancers—approaches grounded in research and practical application. Sleep and circadian rhythm alignment, regular structured cognitive practice (such as spaced repetition and task-specific training), mindfulness and stress regulation, and thoughtful environment and workflow design all serve as core elements. These picks prioritize sustainable habits and task-oriented strategies that align with how cognitive systems are studied to respond under different conditions, rather than relying on single-dose interventions. Safety tips: when evaluating cognitive enhancers, prioritize high-quality information and regulatory context, and consider consulting a qualified professional if you are exploring any pharmacological option. Avoid combining interventions without guidance, be wary of unverified claims, and monitor for unintended effects or changes in how you work and feel. Set realistic expectations, start with non-pharmacological approaches, and track your experiences to understand what supports your focus, memory, and mental clarity within the scope of your goals.