HRT supplement interactions


HRT supplement interactions


supplements that interact with hrt
Oct 18, 2026
Hormone replacement therapy (HRT) can be life-changing for menopausal symptoms, but certain supplements can interfere with its effectiveness or increase risks. In this guide, we break down the most common supplement–HRT interactions, the evidence behind them, and practical tips for safe use. From St. John's wort and DHEA to phytoestrogens and essential nutrients, learn what to avoid, what to consider, and how to talk to your doctor.