Liposomal supplement technology sits at the crossroads of chemistry, materials science, and product development. This page explores liposome science and the specific field of liposomal supplement technology, focusing on how vesicle-based systems are designed, characterized, and manufactured. By centering on structure, materials, and process parameters, it presents a neutral overview of what sets liposomal approaches apart in formulations and product pipelines. At the core are liposomes — nanoscale or microscale spherical vesicles formed from phospholipid bilayers. In liposomal supplement technology, key variables include particle size and distribution, lamellarity (unilamellar vs multilamellar), surface charge, and lipid composition. These factors influence stability, encapsulation behavior, and compatibility with downstream processing. The chapter outlines common production routes such as thin-film hydration, ethanol injection, microfluidic platforms, and extrusion, as well as the purification and sterilization steps that follow. Cutting-edge liposome science within liposomal supplement technology advances through innovations in lipid chemistry, surface engineering, and formulation science. Topics include choice of lipids and cholesterol content, surface modifiers, PEGylation, and the development of more complex architectures like multi-compartment or stimuli-responsive liposomes. Analytical methods—dynamic light scattering, electron microscopy, chromatography, and spectroscopic techniques—are described as essential tools for characterizing size, morphology, surface properties, and encapsulation efficiency. From laboratory demonstrations to scaled production, liposomal supplement technology encompasses quality, reliability, and regulatory considerations. This section discusses design space, process control, batch-to-batch consistency, material sourcing for phospholipids, and documentation practices that support traceability and compliance. It also highlights interdisciplinary collaboration between chemistry, engineering, and quality assurance to advance this technology in a robust, repeatable manner.