prescription drug nutrient depletion refers to the potential for certain medicines to influence the levels of vitamins, minerals, or other nutrients in the body. This concept underscores that medication regimens can interact with nutritional status, and effects can vary between individuals depending on the specific drug, dose, duration, and personal biology. Understanding prescription drug nutrient depletion supports informed conversations with your healthcare team and careful medication planning. Not every prescription carries a depletion risk, but some medicines may alter nutrient balance. The likelihood and magnitude of prescription drug nutrient depletion depend on the medication class, as well as factors such as existing health conditions, age, and other therapies. Your clinician can help determine whether your medications carry depletion risk and what monitoring or testing might be appropriate in your situation. Managing prescription drug nutrient depletion often involves a plan developed with your clinician. Replenishment options may include diet tips and smart supplements, discussed as part of a broader strategy that aligns with your ongoing medication plan and medical history. The aim is a personalized approach, coordinated with your healthcare team, to address nutrient needs within the context of your prescriptions. When to consult your clinician about prescription drug nutrient depletion: if you start a new medication or change a dose, if you notice new symptoms, or if you are considering supplements as part of your plan. A clinician, pharmacist, or dietitian can review your medications for potential depletion, discuss monitoring options, and help determine next steps.