Understanding supplement drug interactions is essential for staying safe. This page focuses on supplement drug interactions you must know to stay safe, helping you prepare questions for your healthcare team and reduce the chance of unexpected effects. Seven supplements often involved in interactions are St. John's wort, ginkgo biloba, garlic, ginseng, echinacea, kava, and valerian. In general terms, these items can affect how other substances are processed in the body or how signals are observed by clinicians. Because interaction patterns can vary, it’s important to verify with a professional before taking them with any prescription medication. Practical tips to avoid risks include: keep an up-to-date list of all supplements you take; share that list with every clinician and pharmacist you see; use a reputable source to check supplement drug interactions before starting anything new; do not modify or stop medications without professional guidance; read product labeling for any warnings about interactions; and report any unusual symptoms promptly. By staying informed about supplement drug interactions and engaging with qualified professionals, you can manage potential risks and make safer choices. If you have questions, reach out to your healthcare provider or pharmacist for guidance.