Discover how vitamins and supplements can skew blood test results by understanding supplement interactions with blood tests. These interactions can occur when substances you’re taking enter the testing process and influence how results are read or interpreted. Focusing on supplement interactions with blood tests helps set expectations for accuracy and context before you undergo testing. Several mechanisms can drive these interactions, including how a supplement might affect the chemistry of a sample, alter enzyme activity, or influence the stability of certain measurements during processing. Because of these possibilities, test results may reflect the presence of a supplement in addition to the primary factor being assessed. Recognizing that supplement interactions with blood tests can occur underscores the importance of complete information about your regimen when scheduling and reporting tests. Practical prep tips include preparing a complete list of every vitamin, mineral, and other supplement you take, along with dosages and the timing of your last dose, and sharing this list with your clinician or the testing site. Bring this information to your appointment so results can be interpreted in the proper context. Also follow any prep instructions provided by the lab, such as fasting or timing guidelines, and ask questions if you’re unsure how your routine might interact with the scheduled tests. On the day of the test, report any recent changes to your supplement regimen and confirm whether you should continue as usual or adjust timing per provider guidance. If you’re uncertain, contact the testing site or your clinician before the sample is collected. By considering supplement interactions with blood tests and staying organized about what you take, you can support more reliable interpretation of your results.