trimethylglycine supplement
trimethylglycine supplement
Betaine (trimethylglycine, or TMG) is a naturally occurring methyl donor found in beets, spinach, and whole grains that supports methylation, helps convert homocysteine into methionine, and regulates cellular water balance as an osmolyte. Clinical evidence is strongest for supplemental TMG lowering elevated homocysteine, with promising research on liver fat metabolism and exercise performance and weaker evidence for mood and cognitive benefits. This guide translates the research into practical decisions: effective doses (typically 1.25-6 g daily), optimal timing, side effects including the TMAO debate, and a neutral checklist for choosing a third-party-tested TMG supplement. It also answers the questions competitors avoid - from the TMG versus betaine HCl confusion to the trimethylglycine-cancer discussion - so you can decide whether TMG belongs in your routine.